Look across the evidence
Compare papers.
The same rubric, side by side. A comparison of claim support—not a contest between fields.
| Criterion | Programmable Cas9: a biochemical claim with strong follow-through |
|---|---|
| Overall claim grade | A 98/100 |
| Claim examined | Cas9 can be directed by complementary guide RNA to cut target DNA in vitro, and an engineered single RNA can combine the guiding functions. |
| Claim support40% weight | 5/5 The mechanistic claim is supported by biochemical and later cellular results. [1–4] |
| Methods & controls20% weight | 5/5 Component-level experiments connect RNA targeting and nuclease activity to DNA cleavage. [1, 2] |
| Independent checks20% weight | 5/5 A separate biochemical study and independent human-cell implementations corroborate the core mechanism. [2–4] |
| Transparency10% weight | 4/5 Methods and supporting material enable inspection; this site has not repeated the laboratory work. [1–4] |
| Claim calibration10% weight | 5/5 The 2012 result demonstrated cleavage and proposed editing potential; cellular implementation and specificity were tested separately. [1, 3–5] |
| Evidence status | Independently corroborated |